Inflammation-Related IL1β/IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma
نویسندگان
چکیده
منابع مشابه
Inflammation-Related IL1β/IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma.
Exposure to asbestos is causally associated with the development of malignant mesothelioma, a cancer of cells lining the internal body cavities. Malignant mesothelioma is an aggressive cancer resistant to all current therapies. Once inhaled or ingested, asbestos causes inflammation in and around tissues that come in contact with these carcinogenic fibers. Recent studies suggest that inflammatio...
متن کاملMalignant mesothelioma: attributable risk of asbestos exposure.
OBJECTIVES To evaluate a case-control study of malignant mesothelioma through patterns of exposure to asbestos based upon information from telephone interviews with next of kin. METHODS Potential cases, identified from medical files and death certificates, included all people diagnosed with malignant mesothelioma and registered during 1975-1980 by the Los Angeles County Cancer Surveillance Pr...
متن کاملGermline Mutation of Bap1 in a Mouse Model Accelerates Development of Asbestos-Induced Malignant Mesothelioma
Running Title: Bap1 +/-mice predisposed to asbestos-induced mesothelioma Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Abstract Malignant mesotheliomas are highly aggressive tumors usually caused by exposure to asbestos. Germline inactivating mutations of BAP1 predispose to mesothelioma and certain other cancers. However, why mesothelioma ...
متن کاملGermline mutation of Bap1 accelerates development of asbestos-induced malignant mesothelioma.
Malignant mesotheliomas are highly aggressive tumors usually caused by exposure to asbestos. Germline-inactivating mutations of BAP1 predispose to mesothelioma and certain other cancers. However, why mesothelioma is the predominate malignancy in some BAP1 families and not others, and whether exposure to asbestos is required for development of mesothelioma in BAP1 mutation carriers are not known...
متن کاملMolecular and Cellular Pathobiology Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma
Malignant mesotheliomas are highly aggressive tumors usually caused by exposure to asbestos. Germlineinactivating mutations of BAP1 predispose to mesothelioma and certain other cancers. However, why mesothelioma is the predominatemalignancy in some BAP1 families and not others, andwhether exposure to asbestos is required for development of mesothelioma in BAP1 mutation carriers are not known. T...
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ژورنال
عنوان ژورنال: Cancer Prevention Research
سال: 2016
ISSN: 1940-6207,1940-6215
DOI: 10.1158/1940-6207.capr-15-0347